368 research outputs found

    The Role of the Narrative in Values-Led Business

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    Many leaders of values-based organizations already possess the requisite passion for the core values of their respective organizations. The ability to have their organizations perform in a manner consistent with these values is critical to gain the authenticity necessary for their audiences in order to discern the value of what that particular organization offers. The inability to articulate this to all stakeholders — including the marketplace, investors, employees, and competitors — may increase the hazard of mortality for the organization. One characteristic that human beings do not share with any other creature on earth is the ability to relate complex narratives. Narratives in leadership are synonymous with storytelling in organizations. Narratives have a much broader connotation. Narratives are an ancient art form and have the ability to create a connection between the narrator and the audience. If related well, it can create a sense of community, hone a common focus, and provide a stimulus for change. Most organizations need to address a common problem of implementing leadership tools resulting in the best outcomes for decisions. Poor leadership will inevitably increase the likelihood of organizational failure. They need to implement mechanisms that will increase positive outcomes. This paper reviews examples of leadership under impossible odds. It will reveal the necessary foundational material to provide a solid background. Next, it will address the common elements of an effective narrative as well as the importance that authenticity plays in its reception. Lastly, the elements of narrative leadership and the power it can give to those leaders who learn how to use narratives effectively will be addressed. Examples will demonstrate how effective narratives used by leaders of values-based organizations can eliminate obstacles and help their organizations perform audaciously

    A Model for Implementing a Successful Sustainability Strategy

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    The process of implementing sustainability within national and international corporate functions requires senior management commitment and a sustainability team which employs the correct leadership knowledge and skills. Additionally, all stakeholders must fully understand, accept, routinely monitor, and participate in the strategy of sustainability. This core business value must also be clearly articulated throughout the organization

    The Values-Based Revolution

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    The key to creating a successful business is not guaranteed by disingenuously going green especially if that term lacks certain definition. Rather, in addition to adopting principles of environmental stewardship, the values-based leader will discover that in freely espousing and implementing principles in the workplace, consumers with like values will often pay a product and/or service premium to patronize a business demonstrating like mindset. This is the true way of achieving business success

    Quantifying the Order of Priorities in Student Choice of Graduate Business Schools: Does Sustainability Matter?

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    Business schools expend resources to attract more and higher-quality applicants to their institutions, yet our understanding of what criteria resonate with those who want to find the right fit with a business school and its programs is, paradoxically enough, either not clear or dated. There is a dearth of research on what business students value, resulting in missed opportunities to engage existing students so as to translate their interests and aspirations into prospects for program design, delivery, and enrollment. One important and often overlooked criterion, for example, is the desire of business students to learn about sustainability. Thus, while most studies aim to discover and quantify the selection criteria in students’ choice of business schools, this paper builds on the aspect of sustainability. We propose a multi-criteria decision analysis (MCDA) methodology that uncovers an array of essential criteria, including sustainability, for schools to consider in future program revision and development efforts. The proposed approach allows schools to be exact with their resource expenditures in areas that are critical to applicants, including those aligned with sustainability, as well as attract larger numbers of more qualified students. Insights from this study show that with the proper approach to understanding business school candidates, it is possible to quantify the order of priorities that students consider when choosing a business school

    Cell proliferation and differentiation kinetics during spermatogenesis in Hydra carnea

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    Spermatogenesis inHydra carnea was investigated. The cell proliferation and differentiation kinetics of intermediates in the spermatogenesis pathway were determined, using quantitative determinations of cell abundance, pulse and continuous labelling with3H-thymidine and nuclear DNA measurements. Testes develop in the ectoderm of male hydra as a result of interstitial cell proliferation. Gonial stem cells and proliferating spermatogonia have cell cycles of 28 h and 22 h, respectively. Stem cells undergo four, five or six cell divisions prior to meiosis which includes a premeiotic S+G2 phase of 20 h followed by a long meiotic prophase (22 h). Spermatid differentiation requires 12–29 h. When they first appear, testes contain only proliferating spermatogonia; meiotic and postmeiotic cells appear after 2 and 3 days, respectively and release of mature sperm begins after 4 days. Mature testes produce about 27,000 sperm per day over a period of 4–6 days: about 220 gonial stem cells per testis are required to support this level of sperm differentiation. Further results indicate that somatic (e.g. nematocyte) differentiation does not occur in testes although it continues normally in ectodermal tissue outside testes. Our results support the hypothesis that spermatogenesis is controlled locally in regions of the ectoderm where testes develop

    Critical Landau Velocity in Helium Nanodroplets

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    The best-known property of superfluid helium is the vanishing viscosity that objects experience while moving through the liquid with speeds below the so-called critical Landau velocity. This critical velocity is generally considered a macroscopic property as it is related to the collective excitations of the helium atoms in the liquid. In the present work we determine to what extent this concept can still be applied to nanometer-scale, finite size helium systems. To this end, atoms and molecules embedded in helium nanodroplets of various sizes are accelerated out of the droplets by means of optical excitation, and the speed distributions of the ejected particles are determined. The measurements reveal the existence of a critical velocity in these systems, even for nanodroplets consisting of only a thousand helium atoms. Accompanying theoretical simulations based on a time-dependent density functional description of the helium confirm and further elucidate this experimental finding

    Uncovering treatment burden as a key concept for stroke care: a systematic review of qualitative research

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    <b>Background</b> Patients with chronic disease may experience complicated management plans requiring significant personal investment. This has been termed ‘treatment burden’ and has been associated with unfavourable outcomes. The aim of this systematic review is to examine the qualitative literature on treatment burden in stroke from the patient perspective.<p></p> <b>Methods and findings</b> The search strategy centred on: stroke, treatment burden, patient experience, and qualitative methods. We searched: Scopus, CINAHL, Embase, Medline, and PsycINFO. We tracked references, footnotes, and citations. Restrictions included: English language, date of publication January 2000 until February 2013. Two reviewers independently carried out the following: paper screening, data extraction, and data analysis. Data were analysed using framework synthesis, as informed by Normalization Process Theory. Sixty-nine papers were included. Treatment burden includes: (1) making sense of stroke management and planning care, (2) interacting with others, (3) enacting management strategies, and (4) reflecting on management. Health care is fragmented, with poor communication between patient and health care providers. Patients report inadequate information provision. Inpatient care is unsatisfactory, with a perceived lack of empathy from professionals and a shortage of stimulating activities on the ward. Discharge services are poorly coordinated, and accessing health and social care in the community is difficult. The study has potential limitations because it was restricted to studies published in English only and data from low-income countries were scarce.<p></p> <b>Conclusions</b> Stroke management is extremely demanding for patients, and treatment burden is influenced by micro and macro organisation of health services. Knowledge deficits mean patients are ill equipped to organise their care and develop coping strategies, making adherence less likely. There is a need to transform the approach to care provision so that services are configured to prioritise patient needs rather than those of health care systems

    Planetary population synthesis

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    In stellar astrophysics, the technique of population synthesis has been successfully used for several decades. For planets, it is in contrast still a young method which only became important in recent years because of the rapid increase of the number of known extrasolar planets, and the associated growth of statistical observational constraints. With planetary population synthesis, the theory of planet formation and evolution can be put to the test against these constraints. In this review of planetary population synthesis, we first briefly list key observational constraints. Then, the work flow in the method and its two main components are presented, namely global end-to-end models that predict planetary system properties directly from protoplanetary disk properties and probability distributions for these initial conditions. An overview of various population synthesis models in the literature is given. The sub-models for the physical processes considered in global models are described: the evolution of the protoplanetary disk, the planets' accretion of solids and gas, orbital migration, and N-body interactions among concurrently growing protoplanets. Next, typical population synthesis results are illustrated in the form of new syntheses obtained with the latest generation of the Bern model. Planetary formation tracks, the distribution of planets in the mass-distance and radius-distance plane, the planetary mass function, and the distributions of planetary radii, semimajor axes, and luminosities are shown, linked to underlying physical processes, and compared with their observational counterparts. We finish by highlighting the most important predictions made by population synthesis models and discuss the lessons learned from these predictions - both those later observationally confirmed and those rejected.Comment: 47 pages, 12 figures. Invited review accepted for publication in the 'Handbook of Exoplanets', planet formation section, section editor: Ralph Pudritz, Springer reference works, Juan Antonio Belmonte and Hans Deeg, Ed

    Performance of the CMS Cathode Strip Chambers with Cosmic Rays

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    The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

    Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe

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    Peptide probes for imaging retinal ganglion cell (RGC) apoptosis consist of a cell-penetrating peptide targeting moiety and a fluorophore-quencher pair flanking an effector caspase consensus sequence. Using ex vivo fluorescence imaging, we previously validated the capacity of these probes to identify apoptotic RGCs in cell culture and in an in vivo rat model of N-methyl- D-aspartate (NMDA)-induced neurotoxicity. Herein, using TcapQ488, a new probe designed and synthesized for compatibility with clinically-relevant imaging instruments, and real time imaging of a live rat RGC degeneration model, we fully characterized time- and dose-dependent probe activation, signal-to-noise ratios, and probe safety profiles in vivo. Adult rats received intravitreal injections of four NMDA concentrations followed by varying TcapQ488 doses. Fluorescence fundus imaging was performed sequentially in vivo using a confocal scanning laser ophthalmoscope and individual RGCs displaying activated probe were counted and analyzed. Rats also underwent electroretinography following intravitreal injection of probe. In vivo fluorescence fundus imaging revealed distinct single-cell probe activation as an indicator of RGC apoptosis induced by intravitreal NMDA injection that corresponded to the identical cells observed in retinal flat mounts of the same eye. Peak activation of probe in vivo was detected 12 hours post probe injection. Detectable fluorescent RGCs increased with increasing NMDA concentration; sensitivity of detection generally increased with increasing TcapQ488 dose until saturating at 0.387 nmol. Electroretinography following intravitreal injections of TcapQ488 showed no significant difference compared with control injections. We optimized the signal-to-noise ratio of a caspase-activatable cell penetrating peptide probe for quantitative non-invasive detection of RGC apoptosis in vivo. Full characterization of probe performance in this setting creates an important in vivo imaging standard for functional evaluation of future probe analogues and provides a basis for extending this strategy into glaucoma-specific animal models
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